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A Dive into Turkey Tail Research

A Dive into Turkey Tail Research

The benefits of turkey tail mushrooms have been known for centuries, but the last few decades we've seen a surge in research and study being done.

I have been watching with much interest since 2008 when the FDA first funded Bastre University in California with $2 million dollars to do research for a variety of different cancers using the Turkey Tail mushroom (Trametes versicolor). Then again in 2012, they received another $5.4 million to zero-in on the potential benefits specifically for breast cancer in woman and prostate cancer in men. 

To say the results are incredible is an understatement. But these are just 2 of the avenues researchers have taken with turkey tail research to determine just how beneficial these mushrooms can be.

Turkey Tail Research

Thus far, researchers have taken to their labs to study a significant number of applications for turkey tail in clinical therapeutic settings.

These are just a few of the studies that exist currently, with more being done every day!

Cancer

Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells https://pubmed.ncbi.nlm.nih.gov/21068144/ 

Antitumor effect of PSK at a distant site: inductions of interleukin-8-like factor and macrophage chemotactic factor in murine tumor https://pubmed.ncbi.nlm.nih.gov/2126000/ 

Coriolus Versicolor and Ganoderma Lucidum Related Natural Products as an Adjunct Therapy for Cancers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials https://pubmed.ncbi.nlm.nih.gov/31333449/ 

Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression https://pubmed.ncbi.nlm.nih.gov/33806255/ 

Polysaccharide K and Coriolus versicolor extracts for lung cancer: a systematic review https://pubmed.ncbi.nlm.nih.gov/25784670/ 

PSK may suppress CD57(+) T cells to improve survival of advanced gastric cancer patients https://pubmed.ncbi.nlm.nih.gov/20229169/ 

Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer https://pubmed.ncbi.nlm.nih.gov/22701186/

Purification, characterization, and antitumor activity of a novel glucan from the fruiting bodies of Coriolus Versicolor https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298263/ 

Immune Support

Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684115/ 

Antigenotoxic Effect of Trametes spp. Extracts against DNA Damage on Human Peripheral White Blood Cells https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517545/

PSP activates monocytes in resting human peripheral blood mononuclear cells: immunomodulatory implications for cancer treatment https://pubmed.ncbi.nlm.nih.gov/23497877/ 

Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China https://pubmed.ncbi.nlm.nih.gov/28595034/

The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010034/ 

The mycelium of the Trametes versicolor (Turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889544/ 

Gut Health

Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial https://pubmed.ncbi.nlm.nih.gov/25006989/ 

A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618583/ 

Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302426/

Antioxidant Properties

Assessment of Bioactive Compounds and Antioxidant Activity of Turkey Tail Medicinal Mushroom Trametes versicolor (Agaricomycetes) http://www.dl.begellhouse.com/journals/708ae68d64b17c52,3d8e7b4f6342518e,4675f12b644a5c81.html 

Mycochemical Investigation of the Turkey Tail Medicinal Mushroom Trametes versicolor (Higher Basidiomycetes): A Potential Application of the Isolated Compounds in Documented Pharmacological Studies http://www.dl.begellhouse.com/journals/708ae68d64b17c52,7b35b5ed6bb0a817,042641d17ec1fb0f.html 

Turkey Tail Medicinal Mushroom, Trametes versicolor (Agaricomycetes), Crude Exopolysaccharides with Antioxidative Activity http://www.dl.begellhouse.com/journals/708ae68d64b17c52,358d19d227c8633b,619a4f915cd02626.html 

Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom, Trametes versicolor (Agaricomycetes), Mitigate Oxidative Stress, Hyperglycemia, and Hyperlipidemia in Rats with Type 2 Diabetes Mellitus http://www.dl.begellhouse.com/journals/708ae68d64b17c52,489762826cea4201,39339ece262c3632.html 

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